Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer.

ABSTRACT:

Background

There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of TILs as a clinical biomarker, a standardised method for their H&E visual evaluation has been validated in breast cancer.

Methods

We sought to investigate the prognostic significance of TILs in a study of 953 invasive epithelial ovarian cancer tumour samples, both primary and metastatic, from 707 patients from the prospective population-based SEARCH study. TILs were analysed using a standardised method based on H&E staining producing a percentage score for stromal and intratumoral compartments. We used Cox regression to estimate hazard ratios of the association between TILs and survival.

Results

The

SUBMITTER: James FR 

PROVIDER: S-EPMC5607562 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature