Validation of a questionnaire to monitor symptoms in HIV-infected patients during hepatitis C treatment.

ABSTRACT:

Background

Clinicians are incorporating patient-reported outcomes in the management of HIV-infected persons co-infected with hepatitis C virus (HCV), but there are no validated inventories to monitor symptoms of patients during HCV therapy.

Design

Five-year retrospective cohort analysis of persons living with HIV (PLWH) treated for HCV.

Methods

The HCV symptom-inventory (HCV-SI) was administered before, during, and after HCV treatment. Discriminant validity was assessed, separately, in mixed model linear regression of HCV-SI T-scores on treatment regimens (pegylated-interferon and ribavirin; pegylated-interferon, ribavirin, and telaprevir; and interferon-free antivirals); and side effect-related premature treatment discontinuation (SE-DC).

Results

From the 103

SUBMITTER: Cachay ER 

PROVIDER: S-EPMC5607579 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature