Neutralizing immune responses induced by oligomeric H5N1-hemagglutinins from plants.

ABSTRACT: Plant-based transient expression is an alternative platform to produce hemagglutinin-based subunit vaccines. This production system provides not only fast and effective response in the context of a pandemic but also enables the supply of big volume vaccines at low cost. Crude plant extracts containing influenza hemagglutinin are considered to use as vaccine sources because of avoidance of related purification steps resulting in low cost production allowing veterinary applications. Highly immunogenic influenza hemagglutinins are urgently required to meet these pre-conditions. Here, we present a new and innovative way to generate functional H5 oligomers from avian flu hemagglutinin in planta by the specific interaction of S·Tag and S·Protein. A S·Tag was fused to H5 trimers and this construc

SUBMITTER: Phan HT 

PROVIDER: S-EPMC5607582 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature