SHARPER Reaction Monitoring: Generation of a Narrow Linewidth NMR Singlet, without X-Pulses, in an Inhomogeneous Magnetic Field.

ABSTRACT: We report a new pure-shift method, termed SHARPER (Sensitive, Homogeneous, And Resolved PEaks in Real time) designed for the analysis of reactions and equilibria by NMR. By focusing on a single selected signal, SHARPER removes all heteronuclear couplings of a selected nucleus without the need to pulse on X channels, thus overcoming hardware limitations of conventional spectrometers. A more versatile decoupling scheme, termed sel-SHARPER, removes all heteronuclear and homonuclear couplings of the selected signal. Both methods are characterized by a periodic inversion of the active spin during the real-time acquisition. In addition to decoupling, they also compensate for pulse imperfections and magnetic field inhomogeneity, generating an extremely narrow singlet with a linewidth approaching

SUBMITTER: Jones AB 

PROVIDER: S-EPMC5607944 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature