Mismatch repair gene polymorphisms and survival in invasive ovarian cancer patients.

ABSTRACT:

Aims

Inherited genetic factors may help partially explain variability of survival length amongst ovarian cancer patients. Of particular interest are genes involved in DNA repair, specifically those involved in mismatch repair (MMR). The aim of this study was to investigate the possible association between the common variants in MMR genes and invasive ovarian cancer overall survival.

Method/results

We examined associations between 44 variants that tag the known common variants (minor allele frequency 0.05) in seven MMR genes (MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2) and survival of invasive ovarian cancer patients in three case-control studies from United Kingdom (UK), Denmark and California of United States of America (USA). DNA from up to 1495 women were genotyped. The

SUBMITTER: Mann A 

PROVIDER: S-EPMC5608075 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature