Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial.

ABSTRACT: Skeletal muscle mitochondrial function declines with age and is a key factor in the maintenance of physical function among older adults. Research studies from animals and humans have consistently demonstrated that exercise improves skeletal muscle mitochondrial function in early and middle adulthood. However, mitochondrial adaptations to both acute and chronic exercise are attenuated in late life. Thus, there is an important need to identify adjuvant therapies capable of augmenting mitochondrial adaptations to exercise (e.g. improved mitochondrial respiration, muscle mitochondria biogenesis) among older adults. This study is investigating the potential of resveratrol supplementation for this purpose. The objective of this randomized, double-masked pilot trial is to evaluate the efficacy of

SUBMITTER: Layne AS 

PROVIDER: S-EPMC5608101 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature