Variability in objective and subjective measures affects baseline values in studies of patients with COPD.

ABSTRACT:

Rationale

Understanding the reliability and repeatability of clinical measurements used in the diagnosis, treatment and monitoring of disease progression is of critical importance across all disciplines of clinical practice and in clinical trials to assess therapeutic efficacy and safety.

Objectives

Our goal is to understand normal variability for assessing true changes in health status and to more accurately utilize this data to differentiate disease characteristics and outcomes.

Methods

Our study is the first study designed entirely to establish the repeatability of a large number of instruments utilized for the clinical assessment of COPD in the same subjects over the same period. We utilized SPIROMICS participants (n = 98) that returned to their clinical center wi

SUBMITTER: Anderson WH 

PROVIDER: S-EPMC5608200 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature