The extent of intrauterine growth restriction determines the severity of cerebral injury and neurobehavioural deficits in rodents.

ABSTRACT:

Background

Cerebral Palsy (CP) is the most common physical pediatric neurodevelopmental disorder and spastic diplegic injury is its most frequent subtype. CP results in substantial neuromotor and cognitive impairments that have significant socioeconomic impact. Despite this, its underlying pathophysiological mechanisms and etiology remain incompletely understood. Furthermore, there is a need for clinically relevant injury models, which a) reflect the heterogeneity of the condition and b) can be used to evaluate new translational therapies. To address these key knowledge gaps, we characterized a chronic placental insufficiency (PI) model, using bilateral uterine artery ligation (BUAL) of dams. This injury model results in intrauterine growth restriction (IUGR) in pups, and animals r

SUBMITTER: Ruff CA 

PROVIDER: S-EPMC5608203 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature