Pathological alterations in liver injury following congestive heart failure induced by volume overload in rats.

ABSTRACT: Heart failure has emerged as a disease with significant public health implications. Following progression of heart failure, heart and liver dysfunction are frequently combined in hospitalized patients leading to increased morbidity and mortality. Here, we investigated the underlying pathological alterations in liver injury following heart failure. Heart failure was induced using a modified infrarenal aortocaval fistula (ACF) in male Wistar rats. Sham operated and ACF rats were compared for their morphometric and hemodynamic data, for histopathological and ultrastructural changes in the liver as well as differences in the expression of apoptotic factors. ACF-induced heart failure is associated with light microscopic signs of apparent congestion of blood vessels, increased apoptosis and brea

SUBMITTER: Shaqura M 

PROVIDER: S-EPMC5608213 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature