Stage specific requirement of platelet-derived growth factor receptor-α in embryonic development.

ABSTRACT:

Background

Platelet-derived growth factor receptor alpha (PDGFRα) is a cell-surface receptor tyrosine kinase for platelet-derived growth factors. Correct timing and level of Pdgfra expression is crucial for embryo development, and deletion of Pdgfra caused developmental defects of multiple endoderm and mesoderm derived structures, resulting in a complex phenotypes including orofacial cleft, spina bifida, rib deformities, and omphalocele in mice. However, it is not clear if deletion of Pdgfra at different embryonic stages differentially affects these structures.

Purpose

To address the temporal requirement of Pdgfra in embryonic development.

Methods

We have deleted the Pdgfra in Pdgfra-expressing tissues at different embryonic stages in mice, examined and quantified the

SUBMITTER: Qian C 

PROVIDER: S-EPMC5608218 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature