Correlation of DAPK1 methylation and the risk of gastrointestinal cancer: A systematic review and meta-analysis.

ABSTRACT:

Objective

One of the critical mechanisms of gastrointestinal cancer pathogenesis is the silencing of death associated protein kinase 1 (DAPK1), which could be caused by aberrant methylation of the promoter. However, the relationship between DAPK1 methylation and the risk of gastrointestinal cancer is still controversial. Hence, we conducted this study to determine the potential correlation.

Methods

Eligible publications were searched in the Pubmed, Embase, and Cochrane Library through November 2016 according to the inclusion criteria and exclusion criteria. Revman 5.3 and Stata 12.0 software were used to analyze the relevant data regarding the association between the frequency of DAPK1 methylation and gastrointestinal cancer.

Results

A total of 22 studies with 2406 pa

SUBMITTER: Yuan W 

PROVIDER: S-EPMC5608298 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature