Mesenchymal stem cell therapy for laryngotracheal stenosis: A systematic review of preclinical studies.

ABSTRACT:

Background

Laryngotracheal stenosis (LTS) can be either congenital or acquired. Laryngeal stenosis is most often encountered after prolonged intubation. The mechanism for stenosis following intubation is believed to be hypertrophic scarring. Mesenchymal stem cells (MSCs) therapy has shown promising results in regenerative medicine. We aimed to systematically review the literature on MSC therapy for stenosis of the conductive airways.

Methods

PubMed, EMBASE, Google Scholar and the Cochrane Library were systematically searched from January 1980-January 2017 with the purpose of identifying all studies addressing the effect of MSC therapy on the airway. We assessed effect on inflammation, fibrosis, and MSC as a component in tissue engineering for treating defects in the airway.<

SUBMITTER: Jakobsen KK 

PROVIDER: S-EPMC5608394 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature