A multi-center field study of two point-of-care tests for circulating Wuchereria bancrofti antigenemia in Africa.

ABSTRACT:

Background

The Global Programme to Eliminate Lymphatic Filariasis uses point-of-care tests for circulating filarial antigenemia (CFA) to map endemic areas and for monitoring and evaluating the success of mass drug administration (MDA) programs. We compared the performance of the reference BinaxNOW Filariasis card test (ICT, introduced in 1997) with the Alere Filariasis Test Strip (FTS, introduced in 2013) in 5 endemic study sites in Africa.

Methodology

The tests were compared prior to MDA in two study sites (Congo and Côte d'Ivoire) and in three sites that had received MDA (DRC and 2 sites in Liberia). Data were analyzed with regard to % positivity, % agreement, and heterogeneity. Models evaluated potential effects of age, gender, and blood microfilaria (Mf) counts in indivi

SUBMITTER: Chesnais CB 

PROVIDER: S-EPMC5608416 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature