Carbon Nanotubes Induced Fibrogenesis on Nanostructured Substrates.

ABSTRACT: While the rapidly evolving nanotechnology has shown promise in electronics, energy, healthcare and many other fields, there is an increasing concern about the adverse health consequences of engineered nanomaterials. To accurately evaluate the toxicity of nanomaterials, in vitro models incorporated with in vivo microenvironment characteristics are desirable. This study aims to delineate the influence of nanotopography on fibrogenic response of normal human lung fibroblasts to multi-walled carbon nanotubes (MWCNTs). Nanoscale gratings and pillars of various heights were fabricated on polydimethylsiloxane substrates. Cell spreading and biomechanics were measured, and fibrogenic responses including proliferation, collagen production and reactive oxygen species generation of the f

SUBMITTER: Wang K 

PROVIDER: S-EPMC5608452 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature