Tumor Xenografts of Human Clear Cell Renal Cell Carcinoma But Not Corresponding Cell Lines Recapitulate Clinical Response to Sunitinib: Feasibility of Using Biopsy Samples.

ABSTRACT:

Background

Parallel development of preclinical models that recapitulate treatment response observed in patients is central to the advancement of personalized medicine.

Objective

To evaluate the use of biopsy specimens to develop patient-derived xenografts and the use of corresponding cell lines from renal cell carcinoma (RCC) tumors for the assessment of histopathology, genomics, and treatment response.

Design, setting, and participants

A total of 74 tumor specimens from 66 patients with RCC were implanted into immunocompromised NOD-SCID IL2Rg^-/- mice. Four cell lines generated from patients' specimens with clear cell pathology were used for comparative studies.

Outcome measurements and statistical analysis

Preclinical models were established and ass

SUBMITTER: Dong Y 

PROVIDER: S-EPMC5608640 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature