Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice.

ABSTRACT: Increased arterial thickness measured with ultrasound correlates with future cardiovascular events, but conventional ultrasound imaging techniques cannot distinguish between intima, media, or atherosclerotic plaque in the carotid artery. In this work, we evaluated how well vascular elastography can detect intimal changes in a mouse model of carotid remodeling. We ligated the left external and internal branches of the carotid artery of male FVB mice and performed sham operations for 2 weeks. High-resolution ultrasound imaging accurately detected lower blood velocities and low blood volume flow in the carotid arteries after ligation in FVB mice. However, ultrasound could not detect differences in the carotid wall even at 2 weeks post-surgery. The Young's modulus was measured based on displac

SUBMITTER: Korshunov VA 

PROVIDER: S-EPMC5608712 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature