Differential regulation of Effector and Regulatory T cell function by Blimp1.

ABSTRACT: The transcriptional regulator Blimp1 plays crucial roles in controlling terminal differentiation in several lineages. In T cells, Blimp1 is expressed in both effector (Teff) and regulatory (Treg) cells, and mice with T cell-specific deletion of Blimp1 (Blimp1CKO mice) spontaneously develop severe intestinal inflammation, indicating a crucial role for Blimp1 in T cell homeostasis regulation. Blimp1 has been shown to function as a direct activator of the Il10 gene and although its requirement for IL10 expression has been demonstrated in both Treg and Teff cells under inflammatory conditions, the intrinsic requirement of Blimp1 for homeostatic maintenance of these T cell subsets had not been investigated. Using mice with Foxp3⁺ Treg-cell specific deletion of Blimp1 and other approa

SUBMITTER: Bankoti R 

PROVIDER: S-EPMC5608714 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature