Modelling compartmentalization towards elucidation and engineering of spatial organization in biochemical pathways.

ABSTRACT: Compartmentalization is a fundamental ingredient, central to the functioning of biological systems at multiple levels. At the cellular level, compartmentalization is a key aspect of the functioning of biochemical pathways and an important element used in evolution. It is also being exploited in multiple contexts in synthetic biology. Accurate understanding of the role of compartments and designing compartmentalized systems needs reliable modelling/systems frameworks. We examine a series of building blocks of signalling and metabolic pathways with compartmental organization. We systematically analyze when compartmental ODE models can be used in these contexts, by comparing these models with detailed reaction-transport models, and establishing a correspondence between the two. We build on th

SUBMITTER: Menon G 

PROVIDER: S-EPMC5608717 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature