Impact of mitochondrial nitrite reductase on hemodynamics and myocardial contractility.

ABSTRACT: Inorganic nitrite (NO₂^-) can be reduced back to nitric oxide (NO) by several heme proteins called nitrite reductases (NR) which affect both the vascular tonus and hemodynamics. The objective of this study was to clarify the impact of several NRs on the regulation of hemodynamics, for which hemodynamic parameters such as heart rate, blood pressure, arterial stiffness, peripheral resistance and myocardial contractility were characterized by pulse wave analysis. We have demonstrated that NO₂^- reduced to NO in RBCs predominantly influences the heart rate, while myoglobin (Mb) and mitochondria-derived NO regulates arterial stiffness, peripheral resistance and myocardial contractility. Using ex vivo on-line NO-detection, we showed that Mb is the strong

SUBMITTER: Dungel P 

PROVIDER: S-EPMC5608763 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature