Formation and purification of tailored liposomes for drug delivery using a module-based micro continuous-flow system.

ABSTRACT: Liposomes are lipid based bilayer vesicles that can encapsulate, deliver and release low-soluble drugs and small molecules to a specific target site in the body. They are currently exploited in several nanomedicine formulations. However, their development and application is still limited by expensive and time-consuming process development and production methods. Therefore, to exploit these systems more effectively and support the rapid translation of new liposomal nanomedicines from bench to bedside, new cost-effective and scalable production methods are needed. We present a continuous process flow system for the preparation, modification and purification of liposomes which offers lab-on-chip scale production. The system was evaluated for a range of small vesicles (below 300 nm) varying in

SUBMITTER: Dimov N 

PROVIDER: S-EPMC5608873 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature