Intestinal microbiota is altered in patients with colon cancer and modified by probiotic intervention.

ABSTRACT:

Objective

The colonic microbiota is altered in patients with colorectal cancer (CRC). We investigated the microbiota composition of patients with colon cancer compared with controls devoid of neoplastic or inflammatory disease and the potential to modify the colonic microbiota with probiotics.

Design

Biopsy samples were obtained from the normal mucosa and tumour during colonoscopy from 15 patients with colon cancer. Subsequent patient-matched samples were taken at surgery from the tumour and nearby mucosa from the patients with cancer, eight of whom had received two daily tablets totalling 1.4×10¹⁰ CFUs Bifidobacterium lactis Bl-04 and 7×10⁹ CFUs Lactobacillus acidophilus NCFM. Faecal samples were obtained after colonoscopy prior to starti

SUBMITTER: Hibberd AA 

PROVIDER: S-EPMC5609083 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature