Altered Functional Connectivity Density in Subtypes of Parkinson's Disease.

ABSTRACT: Parkinson's disease (PD) can be classified into tremor-dominant and akinetic-rigid subtypes, each of which exhibits a unique clinical course and prognosis. The neural basis for these disparate manifestations is not well-understood, however. This study comprehensively investigated the altered functional connectivity patterns of these two subtypes. Twenty-five tremor-dominant patients, 25 akinetic-rigid patients and 26 normal control subjects participated in this study. Resting-state functional MRI data were analyzed using functional connectivity density (FCD) and seed-based functional connectivity approaches. Correlations between neuroimaging measures and clinical variables were also calculated. Compared with normal control, increased global FCD occurred most extensively in frontal lobe and

SUBMITTER: Hu X 

PROVIDER: S-EPMC5609108 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature