Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice.

ABSTRACT: Clinical observations that kidney transplant recipients receiving belatacept who experienced T cell-mediated acute rejection can be successfully treated and subsequently maintained on belatacept-based immunosuppression suggest that belatacept is able to control memory T cells. We recently reported that treatment with CTLA4-Ig from day 6 posttransplantation successfully rescues allografts from acute rejection in a BALB/c to C57BL/6 heart transplant model, in part, by abolishing B cell germinal centers and reducing alloantibody titers. Here, we show that CTLA4-Ig is additionally able to inhibit established T cell responses independently of B cells. CTLA4-Ig inhibited the in vivo cytolytic activity of donor-specific CD8⁺ T cells, and the production of IFNγ by graft-infiltrat

SUBMITTER: Young JS 

PROVIDER: S-EPMC5609110 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature