The Slow Dynamics of Intracellular Sodium Concentration Increase the Time Window of Neuronal Integration: A Simulation Study.

ABSTRACT: Changes in intracellular Na⁺ concentration ([Na⁺]_i) are rarely taken into account when neuronal activity is examined. As opposed to Ca²⁺, [Na⁺]_i dynamics are strongly affected by longitudinal diffusion, and therefore they are governed by the morphological structure of the neurons, in addition to the localization of influx and efflux mechanisms. Here, we examined [Na⁺]_i dynamics and their effects on neuronal computation in three multi-compartmental neuronal models, representing three distinct cell types: accessory olfactory bulb (AOB) mitral cells, cortical layer V pyramidal cells, and cerebellar Purkinje cells. We added [Na⁺]_i as a state variable to these models, and allowed it to

SUBMITTER: Zylbertal A 

PROVIDER: S-EPMC5609115 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature