Association between potassium channel SNPs and essential hypertension in Xinjiang Kazak Chinese patients.

ABSTRACT: The aim of the present study was to examine whether single-nucleotide polymorphisms (SNPs) of β1 subunit of large-conductance Ca²⁺-activated K⁺ channel (KCNMB1) and inwardly rectifying K⁺ channel, subfamily J, member-11 (KCNJ11) are associated with essential hypertension (EH) in Xinjiang Kazak Chinese patients. A polymerase chain reaction-restriction fragment length polymorphism technique was applied to detect the distribution of selected alleles and genotype frequencies in a cohort of Xinjiang Kazak Chinese patients. Samples from 267 patients with EH and 259 normotensive (NT) controls were analyzed. An unconditional logistic regression analysis was used to estimate the odds ratio and 95% confidence interval of the risk factors that are associated with the

SUBMITTER: Han YY 

PROVIDER: S-EPMC5609208 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature