DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism.

ABSTRACT: Plasmodium vivax is the most prevalent parasite species that causes malaria in humans and exclusively infects reticulocytes. Reticulocyte infection is facilitated by P vivax Duffy binding protein (DBP), which utilizes DARC (Duffy antigen receptor for chemokines) as an entry point. However, the selective tropism of P vivax for transferrin receptor (CD71)-positive reticulocytes remained unexplained, given the constitutive expression of DARC during reticulocyte maturation. CD71/RNA double staining of reticulocytes enriched from adult peripheral blood reveals 4 distinct reticulocyte populations: CD71^high/RNA^high (∼0.016%), CD71^low/RNA^high (∼0.059%), CD71^neg/RNA^high (∼0.37%), CD71^neg/RNA^low

SUBMITTER: Ovchynnikova E 

PROVIDER: S-EPMC5609335 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature