Relationship of Genetic Variants With Procedural Pain, Anxiety, and Distress in Children.

ABSTRACT:

Objective

This study used a candidate gene approach to examine genomic variation associated with pain, anxiety, and distress in children undergoing a medical procedure.

Study design

Children aged 4-10 years having an IV catheter insertion were recruited from three Midwestern children's hospitals. Self-report measures of pain, anxiety, and distress were obtained as well as an observed measure of distress. Samples were collected from children and biological parents for analysis of genomic variation. Genotyped variants had known or suspected association with phenotypes of interest. Analyses included child-only association and family-based transmission disequilibrium tests.

Results

Genotype and phenotype data were available from 828 children and 376 family trios. Children

SUBMITTER: Ersig AL 

PROVIDER: S-EPMC5609488 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature