Promotion of invasion by mutant RAS is dependent on activation of the WASF3 metastasis promoter gene.

ABSTRACT: Metastasis represents an end stage in the evolution of cancer progression and has been related to specific genetic pathways. Overexpression of mutant RAS in particular appears to promote invasion and metastasis, although exactly how this occurs has not been well characterized. It was previously showed that activation of the WASF3 protein regulates actin cytoskeleton dynamics that promote invasion. In this report, how WASF3 overexpression interacts with mutant RAS to increase invasion and metastasis was investigated. The ability of RAS to promote invasion and metastasis was shown to be dependent on WASF3 activation in a PI3K and AKT dependent manner. Proteomics analysis demonstrates the presence of AKT in the WASF3 immunocomplex which is enhanced by overexpression of mutant RAS. During thes

SUBMITTER: Teng Y 

PROVIDER: S-EPMC5609680 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature