Parameterization of phosphine ligands demonstrates enhancement of nickel catalysis via remote steric effects.

ABSTRACT: The field of Ni-catalysed cross-coupling has seen rapid recent growth because of the low cost of Ni, its earth abundance, and its ability to promote unique cross-coupling reactions. Whereas advances in the related field of Pd-catalysed cross-coupling have been driven by ligand design, the development of ligands specifically for Ni has received minimal attention. Here, we disclose a class of phosphines that enable the Ni-catalysed Csp³ Suzuki coupling of acetals with boronic acids to generate benzylic ethers, a reaction that failed with known ligands for Ni and designer phosphines for Pd. Using parameters to quantify phosphine steric and electronic properties together with regression statistical analysis, we identify a model for ligand success. The study suggests that effective p

SUBMITTER: Wu K 

PROVIDER: S-EPMC5609847 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature