Interleukin-27 polymorphisms are associated with premature coronary artery disease and metabolic parameters in the Mexican population: the genetics of atherosclerotic disease (GEA) Mexican study.

ABSTRACT: Several studies suggest an important role of Interleukin-27 in the development of atherosclerosis. The aim of this study was to establish whether the IL-27p28 gene polymorphisms are associated with premature coronary artery disease and/or other cardiovascular risk factors. Four IL-27p28 gene polymorphisms were selected and genotyped in 1162 premature coronary artery disease cases and 1107 controls. rs26528 T and rs40837 A alleles were significantly associated with a lower risk of premature coronary artery disease under different inheritance models (P_dominant = 0.046; P_{over-dominant} = 0.002; P_co-dominant1 = 0.007 for rs26528T; P_{over-dominant} = 0.008 and P_co-dominant1 = 0.031 for rs40837). The rs40837 A

SUBMITTER: Posadas-Sanchez R 

PROVIDER: S-EPMC5610017 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature