Conformational selection in amyloid-based immunotherapy: Survey of crystal structures of antibody-amyloid complexes.

ABSTRACT:

Background

The dominant feature in neurodegenerative diseases is protein aggregations that lead to neuronal loss. Immunotherapies using antibodies or antibody fragments to target the aggregations are a highly perused approach. The molecular mechanisms underlying the amyloid-based immunotherapy are complex. Deciphering the properties of amyloidogenic proteins responsible for these diseases is essential to obtain insights into antibody recognition of the amyloid antigens.

Scope of review

We systematically explore all available crystal structures of antibody-amyloid complexes related to neurodegenerative diseases, including antibodies that recognize the Aβ peptide, tau protein, prion protein, alpha-synuclein, huntingtin protein (mHTT), and polyglutamine.

Major conclusions

SUBMITTER: Ma B 

PROVIDER: S-EPMC5610039 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature