Potential Consequences of Not Using Live Attenuated Influenza Vaccine.

ABSTRACT:

Introduction

Decreased live attenuated influenza vaccine (LAIV) effectiveness in the U.S. prompted the Advisory Committee on Immunization Practices in August 2016 to recommend against this vaccine's use. However, overall influenza uptake increases when LAIV is available and, unlike the U.S., LAIV has retained its effectiveness in other countries. These opposing countercurrents create a dilemma.

Methods

To examine the potential consequences of the decision to not recommend LAIV, which may result in decreased influenza vaccination coverage in the U.S. population, a Markov decision analysis model was used to examine influenza vaccination options in U.S. children aged 2-8 years. Data were compiled and analyzed in 2016.

Results

Using recently observed low LAIV effectivenes

SUBMITTER: Smith KJ 

PROVIDER: S-EPMC5610050 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature