Restoration of perivascular adipose tissue function in diet-induced obese mice without changing bodyweight.

ABSTRACT:

Background and purpose

We have recently shown that a reduced function of endothelial nitric oxide synthase (eNOS) in the perivascular adipose tissue (PVAT) contributes crucially to obesity-induced vascular dysfunction in mice. The current study was conducted to test the hypothesis that vascular dysfunction in obesity can be reversed by in vivo improvement of PVAT eNOS activity.

Experimental approach

Male C57BL/6J mice were fed a high-fat diet (HFD) for 22 weeks to induce obesity. During the last 4 weeks of HFD feeding, the obese mice were treated p.o. with the standardized Crataegus extract WS® 1442, which has been shown previously to improve eNOS activity.

Key results

Diet-induced obesity in mice markedly reduced the vasodilator response of thoracic aorta to acetylch

SUBMITTER: Xia N 

PROVIDER: S-EPMC5610154 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature