Antibiotic-induced dysbiosis of the microbiota impairs gut neuromuscular function in juvenile mice.

ABSTRACT:

Background and purpose

Gut microbiota is essential for the development of the gastrointestinal system, including the enteric nervous system (ENS). Perturbations of gut microbiota in early life have the potential to alter neurodevelopment leading to functional bowel disorders later in life. We examined the hypothesis that gut dysbiosis impairs the structural and functional integrity of the ENS, leading to gut dysmotility in juvenile mice.

Experimental approach

To induce gut dysbiosis, broad-spectrum antibiotics were administered by gavage to juvenile (3weeks old) male C57Bl/6 mice for 14 days. Bile acid composition in the intestinal lumen was analysed by liquid chromatography-mass spectrometry. Changes in intestinal motility were evaluated by stool frequency, transit of a flu

SUBMITTER: Caputi V 

PROVIDER: S-EPMC5610159 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature