Similar Evolutionary Trajectories for Retrotransposon Accumulation in Mammals.

ABSTRACT: The factors guiding retrotransposon insertion site preference are not well understood. Different types of retrotransposons share common replication machinery and yet occupy distinct genomic domains. Autonomous long interspersed elements accumulate in gene-poor domains and their nonautonomous short interspersed elements accumulate in gene-rich domains. To determine genomic factors that contribute to this discrepancy we analyzed the distribution of retrotransposons within the framework of chromosomal domains and regulatory elements. Using comparative genomics, we identified large-scale conserved patterns of retrotransposon accumulation across several mammalian genomes. Importantly, retrotransposons that were active after our sample-species diverged accumulated in orthologous regions. This su

SUBMITTER: Buckley RM 

PROVIDER: S-EPMC5610350 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature