Ontology highlight
ABSTRACT:
SUBMITTER: Doll S
PROVIDER: S-EPMC5610546 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Nature chemical biology 20161114 1
Ferroptosis is a form of regulated necrotic cell death controlled by glutathione peroxidase 4 (GPX4). At present, mechanisms that could predict sensitivity and/or resistance and that may be exploited to modulate ferroptosis are needed. We applied two independent approaches-a genome-wide CRISPR-based genetic screen and microarray analysis of ferroptosis-resistant cell lines-to uncover acyl-CoA synthetase long-chain family member 4 (ACSL4) as an essential component for ferroptosis execution. Speci ...[more]