DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer.

ABSTRACT:

Background

The landscape of hereditary syndromes and clinicopathologic characteristics among US Latino/Hispanic individuals with colorectal cancer (CRC) remains poorly understood.

Methods

A total of 265 patients with CRC who were enrolled in the Hispanic Colorectal Cancer Study were included in the current study. Information regarding CRC risk factors was elicited through interviews, and treatment and survival data were abstracted from clinical charts. Tumor studies and germline genetic testing results were collected from medical records or performed using standard molecular methods.

Results

The mean age of the patients at the time of diagnosis was 53.7 years (standard deviation, 10.3 years), and 48.3% were female. Overall, 21.2% of patients reported a first-degree or

SUBMITTER: Ricker CN 

PROVIDER: S-EPMC5610604 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature