Decreased relapsed rate and treatment-related mortality contribute to improved outcomes for pediatric acute myeloid leukemia in successive clinical trials.
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ABSTRACT:
SUBMITTER: Alexander TB
PROVIDER: S-EPMC5610607 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Decreased relapsed rate and treatment-related mortality contribute to improved outcomes for pediatric acute myeloid leukemia in successive clinical trials.
Alexander Thomas B TB Wang Lei L Inaba Hiroto H Triplett Brandon M BM Pounds Stanley S Ribeiro Raul C RC Pui Ching-Hon CH Rubnitz Jeffrey E JE
Cancer 20170530 19
<h4>Background</h4>Outcomes for children with acute myeloid leukemia (AML) have improved over the past 20 years even though the medications used for induction therapy have not changed.<h4>Methods</h4>This study analyzed data from patients with AML who were enrolled in successive protocols (AML97 and AML02) to determine the contributors to the improved outcomes of the latter clinical trial.<h4>Results</h4>There were significant improvements in 5-year overall survival (48.9% vs 71.2%; P < .0001) a ...[more]
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