Progressive Macula Vessel Density Loss in Primary Open-Angle Glaucoma: A Longitudinal Study.

ABSTRACT:

Purpose

To characterize the rate of macula vessel density loss in primary open-angle glaucoma (POAG), glaucoma-suspect, and healthy eyes.

Design

Longitudinal, observational cohort from the Diagnostic Innovations in Glaucoma Study.

Methods

One hundred eyes (32 POAG, 30 glaucoma-suspect, and 38 healthy) followed for at least 1 year with optical coherence tomography angiography (OCT-A) imaging on at least 2 visits were included. Vessel density was calculated in the macula superficial layer. The rate of change was compared across diagnostic groups using a multivariate linear mixed-effects model.

Results

Baseline macula vessel density was highest in healthy eyes, followed by glaucoma-suspect and POAG eyes (P < .01). The rate of vessel density loss was significantly

SUBMITTER: Shoji T 

PROVIDER: S-EPMC5610624 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature