Relationship between Subclinical Thyroid Dysfunction and the Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.

ABSTRACT:

Background

Evidence on the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are conflicting.

Methods and results

PubMed, EMbase, Web of Science, Cochrane Library, and China Biology Medicine (CBM) databases were searched from inception to July 10, 2016. A total of 16 studies were included for meta-analysis. We found that subclinical hypothyroidism was not correlated with coronary heart disease (CHD) (RR = 1.17; 95% CI, 0.91-1.52), total mortality (RR = 1.02; 95% CI, 0.93-1.13), cardiovascular mortality (RR = 1.06; 95% CI, 0.77-1.45), heart failure (RR = 1.17; 95% CI, 0.87-1.57), and atrial fibrillation (RR = 1.05; 95% CI, 0.91-1.21), except CHD mortality (RR = 1.37; 95% CI, 1.03-1.84). Subgroup analysis indicated a higher estimation

SUBMITTER: Sun J 

PROVIDER: S-EPMC5610794 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature