Risk of ESRD and Mortality Associated With Change in Filtration Markers.

ABSTRACT:

Background

Using change in estimated glomerular filtration rate (eGFR) based on creatinine concentration as a surrogate outcome in clinical trials of chronic kidney disease has been proposed. Risk for end-stage renal disease (ESRD) and all-cause mortality associated with change in concentrations of other filtration markers has not been studied in chronic kidney disease populations.

Study design

Observational analysis of 2 clinical trials.

Setting & participants

Participants in the MDRD (Modification of Diet in Renal Disease; n=317) Study and AASK (African American Study of Kidney Disease and Hypertension; n=373).

Predictors

Creatinine, cystatin C, β-trace protein (BTP), and β₂-microglobulin (B2M) were measured in serum samples collected at the 12- an

SUBMITTER: Rebholz CM 

PROVIDER: S-EPMC5610931 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature