Ontology highlight
ABSTRACT:
SUBMITTER: Peng H
PROVIDER: S-EPMC5610937 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Journal of molecular biology 20170814 19
Owing to their high affinities and specificities, rabbit monoclonal antibodies (mAbs) have demonstrated value and potential primarily as basic research and diagnostic reagents, but, in some cases, also as therapeutics. To accelerate access to rabbit mAbs bypassing immunization, we generated a large naïve rabbit antibody repertoire represented by a phage display library encompassing >10 billion independent antibodies in chimeric rabbit/human Fab format and validated it by next-generation sequenci ...[more]