Genome-Wide Association Analysis for Severity of Coronary Artery Disease Using the Gensini Scoring System.

ABSTRACT: Coronary artery disease (CAD) has a complex etiology involving numerous environmental and genetic factors of disease risk. To date, the genetic 9p21 locus represents the most robust genetic finding for prevalent and incident CAD. However, limited information is available on the genetic background of the severity and distribution of CAD. CAD manifests itself as stable CAD or acute coronary syndrome. The Gensini score quantifies the extent CAD but requires coronary angiography. Here, we aimed to identify novel genetic variants associated with Gensini score severity and distribution of CAD. A two-stage approach including a discovery and a replication stage was used to assess genetic variants. In the discovery phase, a meta-analysis of genome-wide association data of 4,930 CAD-subjects assesse

SUBMITTER: Zeller T 

PROVIDER: S-EPMC5611399 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature