Activation of Toll Pathway Is Different between Kuruma Shrimp and Drosophila.

ABSTRACT: The Toll pathway is essential for inducing an immune response to defend against bacterial invasion in vertebrates and invertebrates. Although Toll receptors and the transcription factor Dorsal were identified in different shrimp, relatively little is known about how the Toll pathway is activated or the function of the pathway in shrimp antibacterial immunity. In this study, three Tolls (Toll1-3) and the Dorsal were identified in Marsupenaeus japonicus. The Toll pathway can be activated by Gram-positive (G⁺) and Gram-negative (G^-) bacterial infection. Unlike Toll binding to Spätzle in Drosophila, shrimp Tolls could directly bind to pathogen-associated molecular patterns from G⁺ and G^- bacteria, resulting in Dorsal translocation into

SUBMITTER: Sun JJ 

PROVIDER: S-EPMC5611483 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature