Sw ApoMb Amyloid Aggregation under Nondenaturing Conditions: The Role of Native Structure Stability.

ABSTRACT: Investigation of the molecular mechanisms underlying amyloid-related human diseases attracts close attention. These diseases, the number of which currently is above 40, are characterized by formation of peptide or protein aggregates containing a cross-β structure. Most of the amyloidogenesis mechanisms described so far are based on experimental studies of aggregation of short peptides, intrinsically disordered proteins, or proteins under denaturing conditions, and studies of amyloid aggregate formations by structured globular proteins under conditions close to physiological ones are still in the initial stage. We investigated the effect of amino acid substitutions on propensity of the completely helical protein sperm whale apomyoglobin (sw ApoMb) for amyloid formation from its structured s

SUBMITTER: Katina NS 

PROVIDER: S-EPMC5611671 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature