Influence of genetic variants on renal uric acid handling in response to frusemide: an acute intervention study.

ABSTRACT:

Objectives

Genetic variation in the renal urate transporters SLC2A9 (GLUT9) and SLC22A11 (OAT4) has been reported to interact with diuretics to increase the risk of developing gout. The aim of this study was to determine whether variation in SLC2A9 or SLC22A11 influences acute renal handling of uric acid in response to frusemide.

Methods

Following an overnight fast, healthy participants (n=100) attended a study visit with oral intake of 40 mg frusemide. Blood and urine samples were obtained at baseline and 30, 60, 120 and 180 min after frusemide intake. The primary end point was change in fractional excretion of uric acid (FEUA).

Results

Following intake of frusemide, FEUA initially increased (mean (SD) change from baseline +1.9% (3.0%) at

SUBMITTER: Dalbeth N 

PROVIDER: S-EPMC5611711 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature