Genome-wide association analysis identifies common variants influencing infant brain volumes.

ABSTRACT: Genome-wide association studies (GWAS) of adolescents and adults are transforming our understanding of how genetic variants impact brain structure and psychiatric risk, but cannot address the reality that psychiatric disorders are unfolding developmental processes with origins in fetal life. To investigate how genetic variation impacts prenatal brain development, we conducted a GWAS of global brain tissue volumes in 561 infants. An intronic single-nucleotide polymorphism (SNP) in IGFBP7 (rs114518130) achieved genome-wide significance for gray matter volume (P=4.15 × 10^-10). An intronic SNP in WWOX (rs10514437) neared genome-wide significance for white matter volume (P=1.56 × 10^-8). Additional loci with small P-values included psychiatric GWAS associations and transcri

SUBMITTER: Xia K 

PROVIDER: S-EPMC5611727 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature