Aripiprazole and Riluzole treatment alters behavior and neurometabolites in young ADHD rats: a longitudinal ¹H-NMR spectroscopy study at 11.7T.

ABSTRACT: Attention deficit hyperactivity disorder (ADHD), Tourette syndrome (TS) as well as obsessive compulsive disorder (OCD) are co-occurring neurodevelopmental diseases that share alterations of frontocortical neurometabolites. In this longitudinal study we investigated the behavioral and neurochemical effects of aripiprazole and riluzole treatment in juvenile spontaneously hypertensive rats (SHR), a model for ADHD. For neurochemical analysis we employed in vivo magnetic resonance spectroscopy (MRS). Spectra from voxels located at the central striatum and prefrontal cortex were acquired postnatally from day 35 to 50. In the SHR strain only, treatments reduced repetitive grooming and climbing behavior. The absolute quantification of cerebral metabolites in vivo using localized ¹H-MRS

SUBMITTER: Rizzo F 

PROVIDER: S-EPMC5611734 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature