Genome-wide expression and response to exposure-based psychological therapy for anxiety disorders.

ABSTRACT: Exposure-based psychological treatments for anxiety have high efficacy. However, a substantial proportion of patients do not respond to therapy. Research examining the potential biological underpinnings of therapy response is still in its infancy, and most studies have focussed on candidate genes. To our knowledge, this study represents the first investigation of genome-wide expression profiles with respect to treatment outcome. Participants (n=102) with panic disorder or specific phobia received exposure-based cognitive behavioural therapy. Treatment outcome was defined as percentage reduction from baseline in clinician-rated severity of their primary anxiety diagnosis at post treatment and 6 month follow-up. Gene expression was determined from whole blood samples at three time points usi

SUBMITTER: Roberts S 

PROVIDER: S-EPMC5611743 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature