The neural correlates of obsessive-compulsive disorder: a multimodal perspective.

ABSTRACT: Obsessive-compulsive disorder (OCD) is one of the most debilitating psychiatric conditions. An extensive body of the literature has described some of the neurobiological mechanisms underlying the core manifestations of the disorder. Nevertheless, most reports have focused on individual modalities of structural/functional brain alterations, mainly through targeted approaches, thus possibly precluding the power of unbiased exploratory approaches. Eighty subjects (40 OCD and 40 healthy controls) participated in a multimodal magnetic resonance imaging (MRI) investigation, integrating structural and functional data. Voxel-based morphometry analysis was conducted to compare between-group volumetric differences. The whole-brain functional connectome, derived from resting-state functional connecti

SUBMITTER: Moreira PS 

PROVIDER: S-EPMC5611752 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature